In this editorial, David Powlison argues that practical theology exists within the interplay between the Bible’s richly annotated story and our own life-determining choices. Practical theology brings God and people together, transforming how we think, react, love, decide, choose—it brings truth into life. Powlison concludes by introducing the articles in this issue, written primarily by women—they reflect this emphasis on practical theology: biblical truth meets real-life personal experiences.