In this article, Robert Smith examines the use of Lithium as a medication frequently used in treating psychiatric disorders. Smith discusses the history of the use of Lithium in manic-depression (bipolar) as well as drug action, side effects and outcomes. He points to concerns with the use of Lithium and the idea of a “chemical imbalance” in the body. Smith concludes his article with guidance for the biblical counselor when working with those using Lithium.