In this article, Ed Welch interviews four Christian doctors discuss how they work to think biblically about depression within their practice of medicine. Welch asks questions such as, What do you see in patients? Is there a difference between depressed Christians and depressed non-Christians? Do you have a theory of depression? What do you do when you encounter a patient who is depressed? Do you think medications are appropriate? Do you refer depressed patients for counseling? and How can biblical counseling speak effectively to Christian physicians or psychiatrists?